Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
This 2015 study revealed that high-dose vitamin C selectively induces cytotoxicity in colorectal cancer (CRC) cells with KRAS or BRAF mutations by targeting the glycolytic enzyme GAPDH. The mechanism involves enhanced uptake of dehydroascorbate (DHA) via GLUT1 transporters, followed by intracellular reduction to vitamin C, which consumes glutathione and leads
June 26, 2025
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