This 2013 review by Michael J. Kosnett evaluates the efficacy of chelation therapy for metal poisonings beyond the commonly treated lead, arsenic, and mercury. The paper highlights that while chelation is established for acute exposures to certain metals, its utility in chronic toxicity is often unsupported due to limited evidence.
This 2011 review by Ellen J. Eckes discusses the critical role of nurses in managing iron overload resulting from chronic blood transfusions in conditions like thalassemia and sickle cell disease. Iron overload can lead to damage in vital organs such as the liver, heart, and endocrine glands. The article emphasizes
This 2022 review explores the role of iron overload in breast cancer development and progression. Excess iron, particularly non-transferrin-bound iron (NTBI), can catalyze free radical reactions, leading to oxidative stress and DNA damage. Estrogen can exacerbate this by disrupting iron metabolism, further increasing reactive oxygen species (ROS) production. The study
