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Tag: deferasirox

Chelation therapy for iron overload: nursing practice implications

This 2011 review by Ellen J. Eckes discusses the critical role of nurses in managing iron overload resulting from chronic blood transfusions in conditions like thalassemia and sickle cell disease. Iron overload can lead to damage in vital organs such as the liver, heart, and endocrine glands. The article emphasizes

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June 26, 2025 No Comments

Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach

This 2022 review explores the role of iron overload in breast cancer development and progression. Excess iron, particularly non-transferrin-bound iron (NTBI), can catalyze free radical reactions, leading to oxidative stress and DNA damage. Estrogen can exacerbate this by disrupting iron metabolism, further increasing reactive oxygen species (ROS) production. The study

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June 26, 2025 No Comments