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Tag: cytokine release syndrome

Interleukin 6: at the interface of human health and disease

This 2023 review article published in Frontiers in Immunology (DOI: 10.3389/fimmu.2023.1255533) explores the central role of Interleukin-6 (IL-6) in immune regulation, inflammation, and disease. IL-6 bridges innate and adaptive immunity, influences B and T cell activity, impacts the blood-brain barrier, and contributes to systemic and localized inflammation. The review highlights

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June 26, 2025 No Comments

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

This meta-analysis of 25 studies encompassing 1,245 patients with severe or critical COVID-19 found that average interleukin-6 (IL-6) levels (36.7 pg/mL) were significantly lower than those observed in cytokine release syndrome (3,110.5 pg/mL), sepsis (983.6 pg/mL), and non-COVID-19 acute respiratory distress syndrome (460 pg/mL). These findings question the characterization of

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June 26, 2025 No Comments