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Tag: cytochrome oxidase

Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats

This study investigates the effects of methylene blue on spatial memory retention in rats with cytochrome oxidase inhibition, which impairs memory. Methylene blue was found to restore memory retention by improving mitochondrial function, suggesting its potential to treat neurodegenerative diseases. The study provides evidence that methylene blue enhances memory by

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June 26, 2025 No Comments

Striatal neuroprotection with methylene blue

​This study investigated methylene blue’s (MB) neuroprotective effects in a rat model of striatal damage induced by rotenone (Rot), a mitochondrial toxin. Co-administration of MB significantly reduced the size of Rot-induced lesions, preserved cytochrome oxidase activity, and decreased oxidative stress in the striatum. Additionally, MB maintained functional connectivity in motor

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June 26, 2025 No Comments

Beneficial network effects of methylene blue in an amnestic model

This study evaluated the neuroprotective effects of methylene blue (MB) in an animal model of mitochondrial dysfunction-induced hypometabolism in the posterior cingulate cortex (PCC), a condition linked to memory deficits similar to those seen in Alzheimer’s disease. Rats receiving sodium azide infusions exhibited significant visuospatial memory impairments and reduced cytochrome

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June 26, 2025 No Comments

Extinction memory improvement by the metabolic enhancer methylene blue

This animal study examined the effects of methylene blue (MB), a metabolic enhancer, on extinction memory retention in rats. Results showed that MB-treated rats exhibited significantly lower freezing behavior in response to the conditioned stimulus, indicating improved retention of extinction memory. Additionally, MB increased brain cytochrome oxidase activity by 38%,

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June 26, 2025 No Comments