Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
This 2013 study explores the antiproliferative effects of resveratrol on gastric cancer cells through a Sirt1-dependent pathway. Resveratrol treatment caused significant G1 phase arrest and cellular senescence without inducing apoptosis. Mechanistically, it downregulated cyclin D1, CDK4, and CDK6 while upregulating p21 and p16, halting cell cycle progression. In vivo experiments
June 26, 2025
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