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Tag: ctDNA

Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers

This retrospective study assessed the safety and efficacy of sirolimus, an mTOR inhibitor, combined with endocrine therapy in 36 patients with advanced hormone receptor-positive (HR+) breast cancer. The combination yielded a median progression-free survival (PFS) of 4.9 months and an objective response rate of 19.4%, with a clinical benefit rate

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June 26, 2025 No Comments

Sensitivity of plasma BRAFmutant and NRASmutant cell-free DNA assays to detect metastatic melanoma in patients with low RECIST scores and non-RECIST disease progression

This study evaluated the effectiveness of plasma-based assays detecting BRAF and NRAS mutations in circulating tumor DNA (ctDNA) for monitoring metastatic melanoma. Involving patients with unresectable stage IIIC/IV melanoma undergoing BRAF inhibitor therapy or immune checkpoint blockade, ctDNA levels were measured using droplet digital PCR. The assays demonstrated higher sensitivity

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June 26, 2025 No Comments

Liquid Biopsies for Assessing Metastatic Melanoma Progression

This 2016 study evaluates the utility of liquid biopsies in monitoring metastatic melanoma progression. By analyzing circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in blood samples, the research demonstrates that liquid biopsies can provide real-time insights into tumor dynamics, detect emerging resistance mutations, and assess treatment response. The

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June 26, 2025 No Comments

Methylated circulating tumor DNA in blood: power in cancer prognosis and response

This 2016 review explores the role of methylated circulating tumor DNA (ctDNA) as a non-invasive biomarker in cancer prognosis and treatment monitoring. ctDNA, detectable in plasma or serum, reflects tumor-specific genetic and epigenetic alterations, including aberrant DNA methylation patterns. These methylation changes are often consistent across patients, making them reliable

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June 26, 2025 No Comments