This cohort study, published in Clinical Cancer Research (2009), examined how inflammatory biomarkers relate to fatigue in patients undergoing radiation therapy for early-stage breast and prostate cancer. The study involved 48 participants (28 with breast cancer, 20 with prostate cancer), measuring fatigue levels and serum levels of IL-1β, IL-6, IL-1ra,
This systematic review and meta-analysis examined the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress markers across 66 randomized controlled trials. The results showed significant reductions in C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), along with improvements in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity,
This Cochrane systematic review assessed the diagnostic accuracy of serum or plasma ferritin as an index of both iron deficiency and iron overload. It found that while low ferritin levels reliably indicate iron deficiency, ferritin’s reliability diminishes in the presence of inflammation, where elevated levels may mask true deficiency. Conversely,
This systematic review and meta-analysis examined the effects of L-carnitine supplementation on inflammation and oxidative stress markers by analyzing data from multiple randomized controlled trials. The results indicated that L-carnitine supplementation significantly reduced key inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well
This study from the Women’s Health Initiative Observational Study examined how postmenopausal hormone therapy (PHT) affects biomarkers associated with coronary heart disease (CHD). Results showed that PHT use is linked to increased CRP, HDL, and triglyceride levels, as well as lower tPA-antigen and homocysteine. Estrogen plus progestin use was associated
