Estrogen-containing hormone therapy and Alzheimer’s disease risk: understanding discrepant inferences from observational and experimental research
This 2006 study explores the conflicting findings from observational research and randomized controlled trials regarding the effects of estrogen-containing hormone therapy (HT) on Alzheimer’s disease (AD) risk. Observational studies have often suggested a protective effect of HT against AD, while randomized trials, such as the Women’s Health Initiative Memory Study,