Well Referenced

Tag: critical illness

When a calorie isn’t just a calorie: a revised look at nutrition in critically ill patients with sepsis and acute kidney injury

This 2022 review examines the complexities of nutritional management in critically ill patients with sepsis and acute kidney injury (AKI). It highlights that sepsis induces unique metabolic changes, such as activation of fasting metabolism, which may be protective. Traditional nutrition strategies, often based on inaccurate caloric estimates and not accounting

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June 26, 2025 No Comments

Interleukin-6: obstacles to targeting a complex cytokine in critical illness

This 2021 review article published in The Lancet Respiratory Medicine (DOI: 10.1016/S2213-2600(21)00103-X) delves into the complex biology of interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory roles, and its implications in critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and severe COVID-19. The review highlights IL-6’s multiple

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June 26, 2025 No Comments

Glutamine as an immunonutrient

The 2011 review article “Glutamine as an Immunonutrient” (PMID: 22028151) explores the role of glutamine, the most abundant amino acid in the human body, in maintaining immune function and supporting recovery under stress conditions such as illness, trauma, or surgery. Though not traditionally classified as essential, glutamine becomes conditionally essential

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June 26, 2025 No Comments

Glutamine supplementation

The 2011 review article “Glutamine Supplementation” (Annals of Intensive Care, https://doi.org/10.1186/2110-5820-1-25) evaluates the clinical significance of glutamine as a conditionally essential amino acid during critical illness, particularly in ICU patients receiving total parenteral nutrition (TPN). The review emphasizes that intravenous (IV) glutamine at 0.3–0.5 g/kg/day restores plasma levels, improves immune

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June 26, 2025 No Comments