Well Referenced

Tag: COVID-19 treatment

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

This 2020 study by Yao et al. evaluated the antiviral efficacy of hydroxychloroquine (HCQ) against SARS-CoV-2 in vitro and proposed optimized dosing regimens using physiologically based pharmacokinetic (PBPK) modeling. HCQ demonstrated greater potency than chloroquine, with an EC50 of 0.72 μM compared to 5.47 μM. The PBPK model suggested that

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June 26, 2025 No Comments

A pilot study for treatment of COVID-19 patients in moderate stage using intravenous administration of ozonized saline as an adjuvant treatment-registered clinical trial

This pilot randomized controlled trial evaluated the use of intravenous ozonized saline as an adjunctive treatment for moderate-stage COVID-19 patients. Sixty-four patients were randomly assigned to receive either ozonized saline (n=32) or standard treatment (n=32). The ozonized saline group showed significant improvements in oxygen saturation, reduction in inflammatory markers, and

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June 26, 2025 No Comments