Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn’s Disease: A Randomized Controlled Clinical Trial
This 2018 randomized controlled trial assessed the safety and efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in patients with moderate to severe Crohn’s disease (CD) unresponsive to long-term steroid therapy. Eighty-two patients were enrolled, with 41 receiving four weekly intravenous infusions of 1×10⁶ UC-MSCs/kg. After 12 months, the UC-MSC