This 2016 meta-analysis evaluated the prevalence and prognostic significance of coronary artery calcium (CAC) in 6,739 women with a 10-year ASCVD risk below 7.5%, drawn from five large population-based cohorts. CAC was present in 36.1% of these low-risk women. Over a median follow-up of 7.0 to 11.6 years, the presence
This 2018 review underscores the pivotal role of coronary artery calcium (CAC) scoring in the primary prevention of coronary artery disease (CAD). CAC scoring, obtained through non-contrast CT scans, provides a direct measure of atherosclerotic plaque burden, offering superior risk stratification compared to traditional risk assessment tools. The article highlights
The 2020 ROBINSCA trial, a randomized controlled population-based study in the Netherlands, evaluated the effectiveness of coronary artery calcium (CAC) scoring versus traditional risk factor assessment (SCORE model) for cardiovascular disease (CVD) screening in asymptomatic adults. Participants were randomized into three groups: control (usual care), SCORE-based screening, and CAC-based screening.
This 2017 review article discusses the significance of coronary artery calcium (CAC) scoring in cardiovascular risk assessment. Elevated CAC scores indicate advanced atherosclerosis and a higher risk for cardiovascular disease (CVD), warranting conventional therapies such as aspirin, statins, and lifestyle modifications. The 2013 ACC/AHA guidelines recommend intensified statin therapy for
This 2019 review provides an in-depth examination of coronary artery calcium (CAC) scoring using computed tomography (CT) as a non-invasive method to assess coronary atherosclerosis and guide cardiovascular risk stratification. The article details the technical aspects of performing CAC scans, including acquisition protocols and calculation of the Agatston score. It
This 2019 analysis from the CORE 320 trial assessed 379 symptomatic patients aged 45–85 undergoing coronary artery calcium (CAC) scanning and CT angiography to evaluate the predictive value of different CAC metrics for major adverse cardiac events (MACE) over a two-year follow-up. Among the parameters studied—Agatston score, calcium volume, area,
This 2017 study utilized data from 6,814 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) to evaluate the effectiveness of machine learning, specifically random survival forests, in predicting six cardiovascular outcomes over a 12-year follow-up. Incorporating 735 variables from imaging, biomarker panels, ECG, and questionnaires, the machine learning models outperformed
This cohort study from the Multi-Ethnic Study of Atherosclerosis (MESA) examined whether coronary artery calcium (CAC) progression predicts future coronary heart disease (CHD) events. Over a median follow-up of 7.6 years in 6,778 participants aged 45 to 84, annual CAC increases were linked to higher CHD risk. Those with a
This cohort study from the Multi-Ethnic Study of Atherosclerosis (MESA) evaluated the association between coronary artery calcium (CAC) scores and the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) events in 6,783 participants from diverse ethnic backgrounds. The findings demonstrated that individuals with CAC scores of 0 had ASCVD event rates
This observational study examined how statins influence the progression of coronary artery calcium (CAC) scores and coronary plaque volume in patients with coronary artery disease. The results indicated that statin therapy slowed the progression of both CAC and plaque volume, with the degree of effect varying by statin type. The
