Well Referenced

Tag: collagen

A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation

This 2022 randomized, double-blind, vehicle-controlled study assessed the efficacy, safety, and patient satisfaction of tretinoin 0.05% lotion for chest rejuvenation in 29 patients aged 37–66 years with Fitzpatrick skin types II–IV. Over 180 days, both the tretinoin and vehicle groups demonstrated 30–40% improvement in photodamage, as evaluated by blinded assessors.

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June 26, 2025 No Comments

Treatment of Skin Aging with Topical Estrogens

This 1998 study evaluated the effects of topical estradiol (0.01%) and estriol (0.3%) creams on skin aging in 59 perimenopausal women over six months. Both treatments significantly improved skin elasticity, firmness, and moisture, with reductions in wrinkle depth and pore size ranging from 61% to 100%. Immunohistochemical analysis revealed increased

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June 26, 2025 No Comments

Estrogen-Deficient Skin: The Role of Topical Therapy

This 2019 review discusses the impact of estrogen deficiency on skin aging in postmenopausal women, highlighting symptoms such as dryness, atrophy, fine wrinkling, and poor wound healing. The article evaluates topical treatments, including estrogen creams and soy-derived isoflavones like genistein, which interact with estrogen receptors in the skin. Clinical studies

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June 26, 2025 No Comments

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

This 2017 study evaluated methylene blue (MB) as a potential anti-aging agent for human skin. MB demonstrated potent reactive oxygen species (ROS) scavenging in cultured human skin fibroblasts from both healthy donors and progeria patients. Compared to other antioxidants like N-Acetyl-L-Cysteine (NAC), MitoQ, and MitoTEMPO, MB more effectively stimulated fibroblast

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June 26, 2025 No Comments

Estrogen and skin. An overview

Estrogen plays a crucial role in skin health by maintaining collagen levels, enhancing skin thickness, increasing moisture retention through acid mucopolysaccharides and hyaluronic acid, and supporting wound healing, particularly in postmenopausal women. Both topical and systemic estrogen therapies have been shown to increase skin collagen content, while hormone replacement therapy

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June 26, 2025 No Comments

A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings

This randomized controlled trial examined the effects of LED phototherapy on skin rejuvenation in 76 patients with facial wrinkles, comparing 830 nm LED alone, 633 nm LED alone, a combination of both, and a placebo. Treatments were applied twice weekly for four weeks, with assessments including clinical evaluations, profilometry, histology,

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June 26, 2025 No Comments

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

This review discusses the benefits of oral supplementation with compounds like collagen, astaxanthin, and zinc in improving skin health and preventing aging. These compounds support skin regeneration, reduce wrinkles, and improve hydration and elasticity. The study highlights how nutrition can complement topical treatments, making it a useful addition to skincare

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June 26, 2025 No Comments