This review introduces the “endotoxin hypothesis” of Alzheimer’s disease (AD), proposing that elevated levels of lipopolysaccharide (LPS)—an endotoxin from Gram-negative bacteria—play a significant role in AD pathogenesis. The article discusses how LPS can enter the bloodstream from gut dysbiosis or infections and accumulate in the brain, promoting amyloid-beta (Aβ) production,
This observational study reviewed 218 patient charts from a Rhode Island outpatient Lyme and tick-borne disease clinic, highlighting the challenges in diagnosing and managing post-treatment Lyme disease syndrome (PTLDS). Common symptoms included fatigue (66.5%), joint pain (58.2%), cognitive difficulties (32.1%), and headaches (27.9%). Over half of the patients with symptoms
The study “Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders” (Cell Metabolism, 2022) explores the role of pregnenolone production in hypothalamic pro-opiomelanocortin (POMC) neurons in regulating recognition memory, particularly under metabolic stress conditions like obesity and type 2 diabetes. Researchers found that a short-term high-fat diet impaired
This observational study investigated the effects of hyperbaric oxygen therapy (HBOT) on individuals suffering from long COVID symptoms, particularly fatigue and cognitive dysfunction. Ten participants received 10 HBOT sessions over 12 days, which led to significant improvements in fatigue, executive function, attention, information processing, and verbal function. While no adverse
