This Cochrane systematic review analyzed 49 randomized controlled trials to assess the impact of combination hormonal contraceptives (CHCs) on weight. The findings indicate no substantial evidence linking CHC use to significant weight gain. Trials comparing CHCs to placebo or no intervention showed minimal weight changes, and discontinuation rates due to
This 2024 Cochrane systematic review evaluated the effectiveness of nutritional interventions in preventing and treating pressure ulcers. The review included 32 randomized controlled trials with a total of 10,784 participants. Findings suggest that energy, protein, and micronutrient supplements may slightly increase the number of healed pressure ulcers compared to standard
This 2024 Cochrane systematic review assessed the efficacy and safety of zinc supplementation in preventing and treating the common cold. The analysis included 31 randomized controlled trials with over 2,400 participants. Findings indicated that zinc supplementation may have little or no effect on preventing colds (RR 0.93; 95% CI 0.85–1.01;
This Cochrane systematic review analyzed 29 randomized trials to assess the efficacy of vitamin C in preventing and treating the common cold. The findings indicated that regular vitamin C supplementation (≥200 mg/day) did not significantly reduce the incidence of colds in the general population. However, among individuals exposed to extreme
This 2008 Cochrane systematic review (Cochrane Database Syst Rev, PMID: 18425885) analyzed 21 randomized controlled trials involving 3,484 cancer patients to assess the efficacy, safety, and tolerability of mistletoe (Viscum album) therapy in oncology. While six out of thirteen trials suggested potential survival benefits and fourteen out of sixteen indicated
This Cochrane systematic review assessed the diagnostic accuracy of serum or plasma ferritin as an index of both iron deficiency and iron overload. It found that while low ferritin levels reliably indicate iron deficiency, ferritin’s reliability diminishes in the presence of inflammation, where elevated levels may mask true deficiency. Conversely,
A systematic review from the Cochrane Database of Systematic Reviews (2016) analyzed 71 randomized controlled trials involving 4211 participants to evaluate the efficacy and safety of light-based therapies for acne. The review found that treatments like photodynamic therapy (PDT), lasers, and intense pulsed light (IPL) may reduce acne lesion counts,
A systematic review published in the Cochrane Database of Systematic Reviews (2015) analyzed 12 trials with 201 participants to evaluate the effectiveness of normobaric oxygen therapy (NBOT) and hyperbaric oxygen therapy (HBOT) for treating and preventing migraines and cluster headaches. The findings suggest that NBOT is effective in providing rapid
This Cochrane review investigates the use of hyperbaric oxygen therapy (HBOT) in treating late radiation tissue injury (LRTI) caused by radiotherapy. The review found that while HBOT shows potential in enhancing tissue healing and providing pain relief for LRTI, the evidence is limited, and further studies are needed to confirm
