Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials
A meta-analysis of 11 randomized controlled trials involving 1,216 patients evaluated the effectiveness of thyroxine (T4) monotherapy compared to combination therapy with thyroxine and triiodothyronine (T3) in treating clinical hypothyroidism. The study found no significant differences between the two treatment approaches in alleviating symptoms such as bodily pain, depression, anxiety,