This narrative review examines the role of amino acids (AAs) in parenteral nutrition (PN), emphasizing their critical function in preserving or enhancing muscle mass, particularly in patients unable to meet nutritional needs enterally. It discusses the availability of various industrial PN mixtures and the potential for personalized compounded mixtures tailored
This 2009 hypothesis paper by Daniel J. Cameron critically examines the limitations of existing evidence used to deny antibiotic therapy for chronic Lyme disease (CLD). The author identifies eight key limitations, including inadequate study power, heterogeneity of data, unaddressed risks of long-term illness, and lack of consideration for co-infections and
This 2010 evidence-based review by the Medical Advisory Secretariat assesses the clinical utility and cost-effectiveness of neuroimaging (CT, MRI) in evaluating chronic headaches. The analysis indicates that routine neuroimaging in patients with chronic headaches without neurological abnormalities or “red flags” is of low diagnostic yield and may not be cost-effective.
This commentary by Allen D. Seftel addresses the 2016 international expert consensus on testosterone deficiency (TD) and its treatment. Seftel emphasizes the consensus’s key resolutions, which affirm that TD is a significant medical condition affecting male health and quality of life, and that testosterone therapy (TTh) is effective and evidence-based.
This 2019 review by Salter and Mulhall critically compares testosterone therapy (TTh) guidelines from major international medical societies, including the American Urological Association (AUA), Endocrine Society (ES), European Association of Urology (EAU), and others. The consensus across these guidelines emphasizes that TTh should be reserved for men with confirmed testosterone
This 2003 practice guideline published in Circulation (DOI: 10.1161/01.cir.0000052939.59093.45) by the CDC and AHA evaluates the clinical relevance of inflammatory markers, particularly high-sensitivity C-reactive protein (hs-CRP), in assessing cardiovascular disease (CVD) risk. It concludes that hs-CRP is a useful tool for identifying low-grade systemic inflammation and may enhance cardiovascular risk
This case report details the fatal outcome of a five-year-old autistic child who suffered cardiac arrest due to severe hypocalcemia after mistakenly receiving edetate disodium (EDTA) instead of the safer edetate calcium disodium during chelation therapy. The report highlights the risks of improper chelating agent selection, particularly in pediatric patients,
This review article examines the management of localized prostate cancer, highlighting watchful waiting, radical prostatectomy, and radiation therapy as primary treatment options. It emphasizes that prostate cancer often progresses slowly, particularly in men over 65, making active surveillance a viable option for many patients. The choice of treatment should be
This review article discusses the role of chelation therapy in treating metal intoxication, focusing on the advancements and use of newer, less toxic chelating agents like DMSA and DMPS, which are effective for treating heavy metal poisoning and available in oral form. It highlights DMSA’s potency in treating copper overload
The article titled “Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document” examines the inconsistent benefits of levothyroxine (LT4) and liothyronine (LT3) combination therapy for hypothyroidism, despite its widespread use due to patient-reported benefits. A joint conference by the American, British, and European Thyroid Associations reviewed clinical evidence
