Well Referenced

Tag: Clinical Decision Making

Effect of Seasonal Changes on the Transition Between Subclinical Hypothyroid and Euthyroid Status

This 2013 retrospective longitudinal study analyzed 1,751 individuals with subclinical hypothyroidism and 28,096 euthyroid subjects over a median follow-up of 36 months to assess the impact of seasonal variations on thyroid function. Findings revealed a biphasic pattern in TSH levels, increasing during winter-spring and decreasing in summer-fall. Notably, 57.9% of

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June 26, 2025 No Comments

Prostate cancer–uncertainty and a way forward

This editorial discusses the findings of a study comparing radical prostatectomy to observation in men with localized prostate cancer, emphasizing the uncertainty in determining the optimal management strategy. The study found no significant difference in all-cause mortality between men undergoing surgery and those under observation, though surgery reduced disease-specific mortality

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June 26, 2025 No Comments

Hormone replacement therapy in women with a history of breast cancer

The article reviews hormone replacement therapy (HRT) in women with a history of breast cancer, exploring both its benefits and risks. It finds that while there is no clear evidence linking HRT to a higher risk of breast cancer recurrence, it significantly improves quality of life by managing menopausal symptoms

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June 26, 2025 No Comments