This 20-week prospective study evaluated 420 overweight and obese individuals undergoing a weight-loss program, dividing them into early and late lunch eaters based on a 3:00 PM cutoff. Despite similar total caloric intake, diet composition, energy expenditure, appetite hormones, and sleep duration, late lunch eaters lost significantly less weight and
This 2015 review explores melatonin’s multifaceted role in mitigating brain inflammaging—a chronic, low-grade inflammation contributing to aging and neurodegeneration. Melatonin functions as a direct and indirect antioxidant, modulates mitochondrial function, and suppresses proinflammatory pathways by inhibiting NADPH oxidase, inducible nitric oxide synthase, and proinflammatory cytokines. It also enhances circadian rhythm
This 2015 review examines melatonin’s multifaceted role in inhibiting breast cancer progression. Melatonin exerts cytostatic and cytotoxic effects on breast cancer cells, particularly through MT1 receptor-mediated suppression of estrogen receptor alpha (ERα) expression and activity. It disrupts tumor metabolism by inhibiting the Warburg effect, leading to decreased cell proliferation and
This 2013 review critically examines melatonin’s role in aging, focusing on its interactions with oxidative stress, mitochondrial dysfunction, inflammaging, telomere attrition, and circadian rhythm disruption. Melatonin, a pleiotropic molecule, directly or indirectly influences these interconnected aging processes. The review highlights melatonin’s potential in mitigating age-related damage by enhancing antioxidant defenses,
This observational study investigated the effects of a 10-hour time-restricted eating (TRE) window over 12 weeks in 19 adults with metabolic syndrome (MetS), most of whom were also on statins or antihypertensive medications. TRE led to significant improvements, including an average weight loss of 3.3 kg, reduced waist circumference, BMI,
A hypothesis paper published in Medical Hypotheses (2007) proposes that melatonin plays a central role in the therapeutic effects of red light therapy (RLT). The authors suggest that RLT may enhance melatonin production or activity, contributing to its benefits in conditions such as sleep disorders, mood disturbances, and certain types
This study examines the effects of shift work on hormone levels in male workers, specifically focusing on pregnenolone and testosterone. It found that shift workers exhibited significantly lower serum levels of these hormones compared to daytime workers, likely due to disruptions in their circadian rhythms caused by irregular sleep-wake cycles.
The study “Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults” examines the effects of growth hormone (GH) therapy on metabolic processes and thyroid function in adults with GH deficiency. The findings indicate
This review explores the role of nicotinamide adenine dinucleotide (NAD⁺) and sirtuins in aging and disease, highlighting how declining NAD⁺ levels impair nuclear and mitochondrial function, contributing to age-related conditions such as neurodegenerative diseases. NAD⁺ is a critical coenzyme in redox reactions and regulates enzymes involved in metabolism, circadian rhythms,
