This 2022 systematic review by Wen et al. evaluated the efficacy and safety of ozone therapy in treating chronic wounds, including diabetic foot ulcers (DFUs). The analysis included 12 randomized controlled trials utilizing various ozone delivery methods such as topical applications (ozone gas baths, ozonated oil, ozone water flushing) and
This 2019 systematic review titled “Ozonated Oils and Cutaneous Wound Healing” (Current Pharmaceutical Design, DOI: [10.2174/1381612825666190702100504*) examined numerous experimental and clinical studies on the use of ozonated oils in wound healing. The findings highlight ozonated oils’ potent antimicrobial properties (bactericidal, antiviral, and antifungal), as well as their ability to modulate
This systematic review investigates the effectiveness of hyperbaric oxygen therapy (HBOT) in treating chronic, non-healing wounds, such as diabetic foot ulcers. The analysis revealed that HBOT significantly improves wound healing, with studies showing a 30%-50% improvement in healing rates and enhanced tissue oxygenation. The treatment promotes tissue regeneration through increased
This observational study evaluated the effects of hyperbaric oxygen therapy (HBOT) on plasma antioxidant defenses and wound healing in 14 patients with chronic non-healing wounds over 20 HBOT sessions. The results showed enhanced antioxidant defenses, increased angiogenesis through elevated VEGF and IL-6 levels, improved vascular tone by decreasing endothelin-1 levels,
This meta-analysis examined the effectiveness of hyperbaric oxygen therapy (HBOT) as an adjunctive treatment for chronic lower limb ulcers, particularly diabetic foot ulcers. The review included twelve randomized controlled trials with 577 participants and found that HBOT significantly increased ulcer healing rates at six weeks compared to standard care (risk
