Well Referenced

Tag: chondrocytes

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

This 2017 study by Jeon et al. investigated the role of senescent cells (SnCs) in the progression of post-traumatic osteoarthritis (OA) using a p16-3MR transgenic mouse model. Following anterior cruciate ligament transection (ACLT), SnCs accumulated in the articular cartilage and synovium. Selective elimination of these cells, either genetically or via

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June 26, 2025 No Comments

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

This 2016 study investigated the therapeutic effects of calcitonin on osteoarthritis (OA) using a rat model. Calcitonin administration resulted in reduced cartilage degradation and decreased pain sensitivity. The protective effects were associated with the modulation of Transforming Growth Factor-beta (TGF-β) signaling pathways in chondrocytes, suggesting that calcitonin may exert its

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June 26, 2025 No Comments

Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis

The article titled “Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis” investigates the critical role of glutathione in protecting cartilage from oxidative stress, particularly in the context of aging and osteoarthritis (OA). The study highlights how glutathione maintains redox homeostasis within chondrocytes—cells responsible

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June 26, 2025 No Comments