choline Archives - Well Referenced

The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort

This longitudinal study evaluated the impact of dietary choline intake on cognitive performance and brain structure in 1,391 dementia-free individuals (mean age 61) from the Framingham Offspring Cohort. Dietary data were collected via food frequency questionnaires, and participants underwent neuropsychological testing and MRI imaging. Results indicated that higher concurrent choline

June 26, 2025 No Comments

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats

This 1981 study investigated the combined effects of choline and piracetam on memory and cholinergic function in aged Fischer 344 rats. Rats administered 100 mg/kg of both choline and piracetam showed significantly enhanced retention in a passive avoidance task compared to those given either compound alone. The combination therapy was

June 26, 2025 No Comments

Methionine and choline regulate the metabolic phenotype of a ketogenic diet

This study explored the roles of methionine and choline in regulating the metabolic effects of a ketogenic diet in mice. It found that methionine supplementation helped restore weight and normalized liver fatty acid gene expression, while choline was more effective at reducing liver fat accumulation. The findings suggest that both

June 26, 2025 No Comments

Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia

This animal study investigated the effects of phosphatidylcholine (PC) supplementation on memory performance and brain acetylcholine levels in dementia-model and normal mice. Dementia-model mice exhibited significantly poorer memory and lower brain acetylcholine concentrations than normal controls (p < 0.05). After 45 days of daily PC administration (100 mg), dementia-model mice

June 26, 2025 No Comments

Choline: Exploring the Growing Science on Its Benefits for Moms and Babies

This observational study reviewed the importance of choline intake during pregnancy and lactation, emphasizing its roles in fetal brain development, membrane biosynthesis, neurotransmission, and gene expression. Despite its essential functions, most pregnant women in the U.S. fail to meet the recommended intake of 450 mg/day. Research suggests that adequate choline

June 26, 2025 No Comments

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

This article reviews the crucial role of choline in maintaining liver function, focusing on how choline influences gene expression through epigenetic mechanisms like DNA and histone methylation. Choline is vital for generating S-adenosylmethionine, which regulates liver-related gene expression. A deficiency in choline can lead to liver issues such as fatty

June 26, 2025 No Comments

Tag: choline

The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats

Methionine and choline regulate the metabolic phenotype of a ketogenic diet

Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia

Choline: Exploring the Growing Science on Its Benefits for Moms and Babies

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms