Well Referenced

Tag: cell proliferation

β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression

This 2014 study examined the anticancer effects of β-D-glucan on various breast cancer cell lines, particularly those resistant to endocrine therapy. The compound significantly inhibited cell proliferation in endocrine-resistant lines (LCC9 and LY2) at low micromolar concentrations, while having limited effects on normal breast epithelial cells and triple-negative breast cancer

Read More »
June 26, 2025 No Comments

Successive Treatment with Naltrexone Induces Epithelial-Mesenchymal Transition and Facilitates the Malignant Biological Behaviors of Bladder Cancer Cells

This 2021 in vitro study examined the impact of chronic naltrexone exposure on bladder cancer cell lines (T24 and MB49). It demonstrated that successive treatment enhanced proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, naltrexone induced epithelial-mesenchymal transition (EMT) by downregulating epithelial markers (E-cadherin, CK19) and upregulating mesenchymal markers (N-cadherin,

Read More »
June 26, 2025 No Comments

Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

This 2021 study investigates the antitumor effects of low-dose naltrexone (LDN) on cervical cancer. LDN treatment upregulated the expression of the opioid growth factor receptor (OGFr) and suppressed the PI3K/AKT/mTOR signaling pathway, leading to reduced proliferation, migration, and invasion of cervical cancer cells in vitro. In vivo, LDN inhibited tumor

Read More »
June 26, 2025 No Comments

Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation

This 2014 study investigates the differential sensitivity of non-small cell lung cancer (NSCLC) cell lines to lunasin, a soy-derived peptide with anticancer properties. The research compares lunasin-sensitive H661 cells to resistant H1299 cells, revealing that lunasin internalization is higher in H661 cells. Lunasin interacts with integrins containing αv, α5, β1,

Read More »
June 26, 2025 No Comments

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

This 2014 preclinical study investigates the combined effects of metformin and tamoxifen on estrogen receptor-positive (ER+) breast cancer cells. The combination therapy significantly inhibited cell proliferation, DNA replication, colony formation, and induced apoptosis more effectively than either agent alone. Mechanistically, the enhanced effects are associated with activation of the AMPK

Read More »
June 26, 2025 No Comments

Can nutraceuticals affect the structure of intestinal mucosa? Qualitative and quantitative microanatomy in L-glutamine diet-supplemented weaning piglets

The 2006 study titled “Can nutraceuticals affect the structure of intestinal mucosa? Qualitative and quantitative microanatomy in L-glutamine diet-supplemented weaning piglets” investigated the effects of dietary L-glutamine supplementation on gut morphology in piglets post-weaning. Over a 28-day period, piglets receiving 0.5% L-glutamine showed increased villus height, crypt depth, and cell

Read More »
June 26, 2025 No Comments

The Antioxidant and HDAC-Inhibitor α-Lipoic Acid: Is Synergistic with Exemestane in Estrogen Receptor-Positive Breast Cancer Cells

The in vitro study examined the synergistic effects of the aromatase inhibitor exemestane and the antioxidant/HDAC inhibitor α-lipoic acid on estrogen receptor-positive (ER+) breast cancer cells (MCF-7 and T47D). The combination treatment significantly reduced cell viability, promoted apoptosis, and modulated key apoptosis-related proteins, increasing p21, APAF-1, BIM, and FOXO1 while

Read More »
June 26, 2025 No Comments

Medroxyprogesterone acetate-driven increase in breast cancer risk might be mediated via cross-talk with growth factors in the presence of progesterone receptor membrane component-1

This in vitro study explored the role of medroxyprogesterone acetate (MPA) in increasing breast cancer risk by enhancing cell proliferation in the presence of growth factors, particularly in cells overexpressing progesterone receptor membrane component-1 (PGRMC1). The findings revealed that MPA significantly increased cell proliferation when combined with growth factors, a

Read More »
June 26, 2025 No Comments