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Tag: cell-free DNA

Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis

This 2018 meta-analysis evaluates the diagnostic utility of circulating cell-free DNA (cfDNA) in prostate cancer screening. Analyzing data from multiple studies, the research assesses both quantitative (cfDNA concentration) and qualitative (integrity, methylation patterns) aspects of cfDNA. The findings suggest that cfDNA analysis, particularly when combining quantitative and qualitative measures, can

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June 26, 2025 No Comments

Sensitive tumour detection and classification using plasma cell-free DNA methylomes

This study introduces cfMeDIP-seq, an immunoprecipitation-based method for analyzing methylation patterns in small quantities of circulating cell-free DNA (cfDNA). By profiling the methylomes of cfDNA from plasma samples, the researchers achieved sensitive detection and accurate classification of various cancer types, including early-stage tumors. The approach leverages large-scale, tissue- and cancer-type-specific

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June 26, 2025 No Comments

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

This clinical validation study evaluated a blood-based multi-cancer early detection (MCED) test that analyzes cell-free DNA (cfDNA) methylation patterns using targeted sequencing and machine learning. Conducted as part of the CCGA study, the analysis included 4,077 participants (2,823 with cancer, 1,254 without). The test achieved a specificity of 99.5% and

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June 26, 2025 No Comments