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Tag: celecoxib

Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

This 2016 multicentre, double-blind, non-inferiority trial (MOVES) assessed the efficacy and safety of a fixed-dose combination of chondroitin sulfate (400 mg) and glucosamine hydrochloride (500 mg) taken three times daily versus celecoxib (200 mg once daily) over 6 months in 606 patients with Kellgren and Lawrence grade 2–3 knee osteoarthritis

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June 26, 2025 No Comments

Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT)

This 2017 randomized, double-blind, placebo- and celecoxib-controlled trial evaluated the efficacy and safety of pharmaceutical-grade chondroitin sulfate (CS) 800 mg/day in 604 patients with symptomatic knee osteoarthritis over 6 months. CS demonstrated a statistically significant reduction in pain (−42.6 mm on VAS) and improvement in function (−4.7 on Lequesne Index)

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June 26, 2025 No Comments