Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells
This 2014 study explores the requirement of nucleostemin (NS), a stem/progenitor cell marker, in mediating the anti-proliferative action of indole-3-carbinol (I3C) in human breast cancer cells, particularly HER2-overexpressing 10AT-Her2 cells. These cells exhibit cancer stem cell-like traits (CD44+/CD24−/low and high ALDH-1 activity). Treatment with I3C significantly inhibited tumorsphere formation and
June 26, 2025
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