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Tag: caspase activation

Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1

This study investigated the pro-apoptotic effects of ursolic acid (UA) on human prostate cancer LNCaP cells. UA treatment resulted in significant inhibition of cell proliferation and induction of apoptosis, as evidenced by increased activities of caspase-3 and caspase-9. Mechanistically, UA activated the ROCK1/PTEN signaling pathway, leading to the dephosphorylation and

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June 26, 2025 No Comments

Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants

This 2019 review addresses the persistent racial disparities in prostate cancer (PC) incidence and mortality, particularly among African American men. It explores the potential of three medicinal plants—curcumin, garlic (Allium sativum), and Vernonia amygdalina—as chemopreventive and therapeutic agents against PC. These plants have demonstrated anti-cancer properties, including inhibition of cell

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June 26, 2025 No Comments

Melatonin influences pancreatic cancerogenesis

This 2014 review explores melatonin’s multifaceted role in modulating pancreatic cancer development. Melatonin acts as a potent antioxidant, scavenging reactive oxygen and nitrogen species, and enhancing antioxidant enzyme activity, thereby protecting pancreatic tissue from oxidative stress and inflammation. In pancreatic carcinoma cell lines, high doses of melatonin promote apoptosis via

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June 26, 2025 No Comments