This 2004 case series examines the clinical experiences of eight adult patients who utilized pharmacotherapy for obesity management over a period exceeding 10 years. The medications used included agents such as phentermine and sibutramine. Patients reported sustained weight loss, perceived benefits, and an absence of significant side effects. Notably, there
This 2014 retrospective case series evaluated the use of intravenous (IV) magnesium sulfate as an acute treatment for headaches in pediatric patients aged 13–18 years. Out of 34 episodes reviewed, 20 met inclusion criteria, comprising 5 cases of migraine, 4 tension-type headaches, and 11 status migrainosus. Patients received a standard
This 2008 case series explored the use of topical cyclosporine as a novel treatment for pyoderma gangrenosum (PG), a painful and ulcerative neutrophilic dermatosis commonly linked to systemic conditions like inflammatory bowel disease and rheumatoid arthritis. Four patients applied topical cyclosporine to affected areas, resulting in successful lesion healing without
This 2006 case series evaluated three patients with advanced cancers who received high-dose intravenous vitamin C (IVC) therapy. Each patient experienced unexpectedly prolonged survival and clinical improvement. Pharmacokinetic data indicated that IVC achieves plasma concentrations (~14,000 μmol/L) significantly higher than oral administration, levels at which vitamin C exhibits selective cytotoxicity
This 2014 prospective case series evaluated the safety and potential efficacy of a metabolic therapy regimen in 10 patients with advanced, chemoresistant metastatic cancers. The treatment combined intravenous alpha-lipoic acid (600 mg), oral hydroxycitrate (500 mg three times daily), and low-dose naltrexone (5 mg at bedtime). Patients included those with
This 2015 case series documents the administration of high-dose intravenous vitamin C (IVC) therapy (25–100 g/day) in nine cancer patients of varying stages in Singapore. The study observed instances of survival beyond expected prognosis, improved quality of life, and enhanced tolerance to conventional therapies. Notably, some patients experienced clinical deterioration
This 2015 retrospective observational study (The Permanente Journal, PMID: 26517439) investigated the use of high-dose, fever-inducing Viscum album (European mistletoe) extract as an adjunctive therapy to prevent bladder cancer recurrence in eight patients, seven of whom had nonmuscle-invasive disease. Over a median follow-up of 48.5 months, five patients showed a
This article presents a case series of six patients who initially experienced symptoms commonly attributed to thyroid dysfunction, such as fatigue and depression. However, these symptoms were alleviated by targeting suboptimal gastrointestinal health rather than treating the thyroid directly. Interventions focusing on the gut led to improvements in thyroid function
