Well Referenced

Tag: cartilage regeneration

Safety and Efficacy of Allogenic Placental Mesenchymal Stem Cells for Treating Knee Osteoarthritis: A Pilot Study

This double-blind, placebo-controlled pilot study evaluated the safety and efficacy of intra-articular injections of allogenic placental mesenchymal stem cells (MSCs) in 20 patients with symptomatic knee osteoarthritis (OA). Participants received either 0.5–0.6 × 10⁸ allogenic placenta-derived MSCs or saline placebo. Over 24 weeks, the MSC group demonstrated significant improvements in

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June 26, 2025 No Comments

Comparison efficacy of ESWT and Wharton’s jelly mesenchymal stem cell in early osteoarthritis of rat knee

This 2019 preclinical study evaluated the therapeutic effects of extracorporeal shockwave therapy (ESWT), Wharton’s jelly-derived mesenchymal stem cells (WJMSCs), and their combination in a rat model of early knee osteoarthritis (KOA). All treatment modalities significantly improved cartilage integrity and subchondral bone remodeling, as evidenced by pathological assessments, micro-CT, and immunohistochemical

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June 26, 2025 No Comments

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

This 2017 study by Jeon et al. investigated the role of senescent cells (SnCs) in the progression of post-traumatic osteoarthritis (OA) using a p16-3MR transgenic mouse model. Following anterior cruciate ligament transection (ACLT), SnCs accumulated in the articular cartilage and synovium. Selective elimination of these cells, either genetically or via

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June 26, 2025 No Comments