This 2011 review by Itabe et al. examines the role and behavior of oxidized low-density lipoprotein (OxLDL) in the pathogenesis of atherosclerosis. Contrary to the traditional view of OxLDL as a static plaque component, the study emphasizes the dynamic exchange of OxLDL between the circulation and arterial wall during different
This meta-analysis examined the association between 8-hydroxy-2-deoxyguanosine (8-OHdG) levels and cardiovascular disease (CVD), analyzing 14 studies with 810 CVD patients and 1,106 controls. Results showed significantly higher 8-OHdG levels in CVD patients compared to controls (standard mean difference: 1.04, 95% CI: 0.61–1.47, p < 0.001), with elevated levels observed in
This study from the Women’s Health Initiative Observational Study examined how postmenopausal hormone therapy (PHT) affects biomarkers associated with coronary heart disease (CHD). Results showed that PHT use is linked to increased CRP, HDL, and triglyceride levels, as well as lower tPA-antigen and homocysteine. Estrogen plus progestin use was associated
