Well Referenced

Tag: carcinogenesis

Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications

This comprehensive review explores the multifaceted nature of iron toxicity, emphasizing the role of labile iron species in generating reactive oxygen species (ROS) that lead to oxidative stress, lipid peroxidation, and cellular damage. It discusses the molecular interactions of iron with dietary components, pharmaceuticals, and environmental toxins, highlighting their contribution

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June 26, 2025 No Comments

The gut microbiota, bacterial metabolites and colorectal cancer

This 2014 review explores the role of the gut microbiota and its metabolites in colorectal cancer (CRC) development. It highlights how microbial dysbiosis and the resulting metabolic byproducts can influence carcinogenesis. Beneficial metabolites like short-chain fatty acids (SCFAs) such as butyrate support colon health by reducing inflammation and promoting apoptosis

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June 26, 2025 No Comments

Metformin: do we finally have an anti-aging drug?

This review by Vladimir N. Anisimov explores the potential of antidiabetic biguanides, particularly metformin, as anti-aging agents. Drawing from studies in various organisms—including nematodes, fruit flies, and rodents—the article highlights how metformin reduces hyperglycemia and hyperinsulinemia, factors implicated in aging and cancer. Metformin’s mechanisms involve decreasing insulin resistance and modulating

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June 26, 2025 No Comments

Free radicals, metals and antioxidants in oxidative stress-induced cancer

The article “Free radicals, metals and antioxidants in oxidative stress-induced cancer” explores the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in cellular processes, highlighting their dual nature in cancer development. While these species can function as secondary messengers in signaling pathways that promote oncogenesis, they can

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June 26, 2025 No Comments

Cancer risk and oxidative DNA damage in man

This review explores the relationship between oxidative DNA damage and cancer risk in humans, highlighting how reactive oxygen species (ROS) contribute to DNA lesions that may lead to mutations and carcinogenesis. It discusses the body’s defense mechanisms against oxidative stress and the potential role of antioxidants in cancer prevention. The

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June 26, 2025 No Comments

Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index

This observational study examined the relationship between oxidative DNA damage, measured by urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion, and lifestyle factors such as smoking, gender, and body mass index (BMI) in 121 healthy individuals aged 25-64. Results showed that smokers had a 50% higher 8-OHdG excretion than non-smokers (p

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June 26, 2025 No Comments

Active and passive smoking and lifestyle determinants of 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human leukocyte DNA

This observational study examined the impact of active and passive smoking on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in leukocyte DNA. Findings revealed that active smokers exhibited significantly higher oxidative DNA damage compared to non-smokers, while passive smokers also had elevated levels, though to a lesser extent. Other

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June 26, 2025 No Comments