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Tag: calcium signaling

Is Lead Exposure the Principal Cause of Essential Hypertension?

This review investigates the role of lead exposure in the development of essential hypertension. Epidemiological studies have identified a positive association between lead exposure and increased blood pressure, with some studies suggesting a dose-response relationship. Mechanistic studies indicate that lead may contribute to hypertension through pathways involving oxidative stress, endothelial

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June 26, 2025 No Comments

Endothelial Dysfunction Induced by Cadmium and Mercury and its Relationship to Hypertension

This review article explores the mechanistic links between cadmium (Cd) and mercury (Hg) exposure, endothelial dysfunction, and hypertension. Both metals are shown to induce oxidative stress and reduce nitric oxide (NO) bioavailability, impairing endothelial-dependent vasodilation and promoting vascular stiffness. Cd and Hg disrupt calcium signaling, increase reactive oxygen species (ROS),

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June 26, 2025 No Comments

Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca2+ fluctuations

This study explored quercetin’s effects on pseudo-allergic reactions, particularly those mediated by the Mrgprx2 receptor in mast cells. In vivo, quercetin reduced Evans blue leakage and paw swelling, indicating suppressed allergic responses. In vitro, it inhibited calcium influx and mast cell degranulation by disrupting the PLCγ-IP3R signaling pathway. Molecular docking

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June 26, 2025 No Comments