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Tag: calcitonin

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

This 2016 study investigated the therapeutic effects of calcitonin on osteoarthritis (OA) using a rat model. Calcitonin administration resulted in reduced cartilage degradation and decreased pain sensitivity. The protective effects were associated with the modulation of Transforming Growth Factor-beta (TGF-β) signaling pathways in chondrocytes, suggesting that calcitonin may exert its

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June 26, 2025 No Comments

Calcitonin, the forgotten hormone: does it deserve to be forgotten?

This 2015 review examines calcitonin, a 32-amino acid hormone secreted by thyroid C-cells, focusing on its physiological role and clinical relevance. Calcitonin is stimulated by elevated serum calcium and gastrointestinal hormones like gastrin, contributing to the prevention of hypercalcemia. It also stimulates renal production of 1,25-dihydroxyvitamin D at a site

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June 26, 2025 No Comments

The effect of calcitonin on growth hormone secretion in man

This clinical trial investigated the effects of human calcitonin on growth hormone (GH) secretion in healthy male subjects. The study found that calcitonin suppressed spontaneous GH surges and reduced GH responses to both insulin-induced hypoglycemia and growth hormone-releasing hormone (GHRH). Additionally, calcitonin led to a transient increase in plasma prolactin

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June 26, 2025 No Comments