This 2018 review published in Subcellular Biochemistry (PMID: 30779015) explores the evolving relationship between gut microbiota and aging, synthesizing research from model organisms such as Drosophila melanogaster, killifish, mice, and Caenorhabditis elegans. It highlights how age-associated changes in gut microbial composition may not only reflect aging but actively contribute to
This study investigates the effects of S-linolenoyl glutathione (lin-SG) supplementation on lifespan and stress resistance in Caenorhabditis elegans. The supplementation of lin-SG resulted in extended lifespan and increased resistance to oxidative stress, including protection against amyloid-beta and hydrogen peroxide-induced damage. The mechanism behind these benefits involves the upregulation of Sir-2.1,
This 2018 review published in Cellular and Molecular Life Sciences (PMID: 29026921) examines how age-related changes in gut microbiota contribute to health decline, drawing from studies in invertebrate models like Drosophila melanogaster and Caenorhabditis elegans. The review highlights how dysbiosis during aging disrupts intestinal homeostasis, increases gut permeability, triggers immune
