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Tag: Branched-chain amino acids

Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease

This 2022 review article examines the role of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in metabolic health and disease. Elevated BCAA levels are linked to insulin resistance, type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). BCAAs activate the mTORC1 pathway, influencing cell growth and glucose metabolism.

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June 26, 2025 No Comments

The role of BCAA metabolism in metabolic health and disease

This 2024 review article explores the complex role of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in metabolic health and disease. BCAAs are essential amino acids involved in protein synthesis and energy production. The review highlights that while BCAAs are vital for muscle growth and are commonly used as dietary supplements,

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June 26, 2025 No Comments

Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

This systematic review analyzed 24 studies to assess the effects of oral branched-chain amino acids (BCAAs) supplementation on athletic performance, body composition, recovery, and biochemical responses. The findings indicated that while BCAAs can activate anabolic signaling pathways, their benefits on performance and body composition are negligible. Some studies reported that

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June 26, 2025 No Comments

Branched-chain amino acid supplementation does not enhance athletic performance but affects muscle recovery and the immune system

This 2008 review examined the effects of branched-chain amino acid (BCAA) supplementation on athletic performance, muscle recovery, and immune function. The findings indicate that while BCAA supplementation does not enhance athletic performance, it offers benefits in reducing exercise-induced muscle damage and promoting muscle-protein synthesis. Additionally, BCAA intake before and after

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June 26, 2025 No Comments

Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men

The 2021 study titled “Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men” (PMID: 33123769) explored how long-term exercise affects BCAA metabolism, insulin sensitivity, and liver fat content in sedentary men with and without dysglycaemia. The findings revealed that exercise

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June 26, 2025 No Comments

Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men

The 2022 study titled “Caloric Restriction Improves Glycaemic Control Without Reducing Plasma Branched-Chain Amino Acids or Keto-Acids in Obese Men” (PMID: 36369511) evaluated the effects of a 6-week very-low-calorie diet (VLCD) in overweight, non-diabetic men. While the intervention led to significant weight loss and improved insulin sensitivity (HOMA-IR reduced from

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June 26, 2025 No Comments

Diabetes and branched-chain amino acids: What is the link?

The 2018 editorial “Diabetes and Branched-Chain Amino Acids: What Is the Link?” (PMID: 29369529) explores the consistent association between elevated branched-chain amino acid (BCAA) levels and the development of insulin resistance and type 2 diabetes mellitus (T2DM). It discusses how impaired BCAA catabolism may lead to mitochondrial dysfunction and metabolic

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June 26, 2025 No Comments

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

This randomized controlled trial published in Diabetologia (2015) examined the effects of combined resistance and aerobic exercise training on insulin sensitivity, branched-chain amino acid (BCAA) metabolism, and glycine levels in overweight adults. Over a 6-month period, sedentary participants with a BMI ≥25 (n=119) followed a supervised exercise protocol. The study

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June 26, 2025 No Comments

Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions

This review explores the physiological and pathological roles of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in protein synthesis, energy metabolism, and neurological function. It highlights how BCAAs act as metabolic regulators and substrates in protein and neurotransmitter synthesis, particularly glutamate in the brain. The review notes that imbalances in BCAA

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June 26, 2025 No Comments