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Tag: brain energy metabolism

The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats

This study explored the effects of acute methylene blue (MB) administration on cerebral blood flow (CBF) and metabolism in healthy humans and rats. Contrary to expectations that MB would enhance cerebral metabolism, intravenous administration (0.5–1 mg/kg in humans; 2–4 mg/kg in rats) led to significant, dose-dependent reductions in global CBF

June 26, 2025 No Comments

Extinction memory improvement by the metabolic enhancer methylene blue

This animal study examined the effects of methylene blue (MB), a metabolic enhancer, on extinction memory retention in rats. Results showed that MB-treated rats exhibited significantly lower freezing behavior in response to the conditioned stimulus, indicating improved retention of extinction memory. Additionally, MB increased brain cytochrome oxidase activity by 38%,

June 26, 2025 No Comments