This neuroimaging study assessed how obesity impacts brain structure across the adult lifespan using MRI data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort. Analyzing 527 individuals aged 20–87, researchers found that overweight and obese adults—especially those in midlife—had significantly reduced white matter volume compared to their lean
This 2019 review highlights the central role of NAD⁺ in neuronal health, emphasizing its involvement in energy metabolism, DNA repair, mitochondrial function, and stress responses. The authors discuss how declining NAD⁺ levels with age contribute to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and ALS. NAD⁺-dependent enzymes, including sirtuins and
This in vitro study examines the combined antioxidant effects of N-Acetylcysteine (NAC), Vitamin D3, and Glutathione on intestinal and neuronal barriers. The results demonstrated that this combination effectively crossed both barriers and showed significant neurological benefits, including a 10.5% reduction in inflammation, a 20.4% improvement in cell myelination, and an
