Well Referenced

Tag: bone resorption

The role of the immune system in the physiopathology of osteoporosis

This 2012 review examines the interconnection between the immune system and bone metabolism, particularly in the context of osteoporosis. It focuses on the role of immune cells—especially T and B lymphocytes—in promoting osteoclastogenesis through the secretion of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. Estrogen deficiency enhances this cytokine

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June 26, 2025 No Comments

Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

The study titled “Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss” explores the impact of pregnenolone (Preg) on osteoclast differentiation and bone resorption. The research demonstrated that Preg inhibits RANKL-induced osteoclast differentiation and bone resorption by downregulating specific osteoclast marker genes and suppressing

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June 26, 2025 No Comments