This meta-analysis of 10 clinical trials evaluated duloxetine’s impact on body weight in patients with major depressive disorder (MDD). Short-term treatment (8–9 weeks) with duloxetine (40–120 mg/day) resulted in modest weight loss (mean: -0.5 to -0.6 kg), likely due to side effects such as decreased appetite and nausea. Long-term treatment
This 2019 randomized cross-over trial investigated the effects of a whole grain-rich diet compared to a refined grain diet on body weight, systemic inflammation, and gut microbiome composition in 60 Danish adults at risk of metabolic syndrome. Participants underwent two 8-week dietary intervention periods, separated by a washout period of
This umbrella review analyzes the effects of polyphenols on anthropometric measures and cardiometabolic risk factors in individuals with overweight and obesity. Polyphenol supplementation led to significant reductions in body weight, body mass index (BMI), waist circumference, and fasting blood glucose levels. Additionally, improvements were seen in cholesterol levels, blood pressure,
A meta-analysis of 11 randomized controlled trials involving 1,216 patients evaluated the effectiveness of thyroxine (T4) monotherapy compared to combination therapy with thyroxine and triiodothyronine (T3) in treating clinical hypothyroidism. The study found no significant differences between the two treatment approaches in alleviating symptoms such as bodily pain, depression, anxiety,
The randomized controlled trial titled “Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism” (JAMA, 2003, PMID: 14665656) investigated whether combination therapy with levothyroxine (T4) and liothyronine (T3) provided additional benefits compared to T4 alone in patients with primary hypothyroidism. In this study of 46 patients aged 24–65
