This 2023 randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of once-weekly semaglutide (2.4 mg) in 201 adolescents aged 12 to
This 2014 prospective study evaluated the effects of combining orlistat (120 mg three times daily) with lifestyle modifications (low-calorie diet and exercise) over six months in 101 women with PCOS and 29 BMI-matched controls. Both groups experienced significant BMI reductions. In the PCOS group, there were notable improvements in insulin
This 2013 randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of a novel herbal formulation, Meratrim, comprising extracts from Sphaeranthus indicus and Garcinia mangostana, in 60 obese subjects (BMI 30–40 kg/m²). Participants received 400 mg of the herbal blend or placebo twice daily for 8 weeks, alongside a
This 2013 double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Litramine IQP-G-002AS, a natural fiber complex derived from Opuntia ficus-indica, in promoting weight loss among 125 overweight and obese adults. Participants received either 3 g/day of Litramine or a placebo for 12 weeks, alongside nutritional counseling and a
This 2013 double-blind, randomized controlled trial assessed the efficacy of acarbose (100 mg three times daily) combined with a low-calorie diet and exercise over 20 weeks in 66 non-diabetic overweight or obese adults (BMI 25–35 kg/m²) in Kerman, Iran. Both treatment and placebo groups followed the same diet and exercise
This 1-year, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of zonisamide, an antiepileptic drug, for weight reduction in 225 obese adults (mean BMI 37.6 kg/m²) without diabetes. Participants received daily doses of placebo, 200 mg zonisamide, or 400 mg zonisamide, alongside diet and lifestyle counseling. At 12 months,
This 3-month, randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of exenatide, a GLP-1 receptor agonist, in 26 adolescents aged 12–19 years with severe obesity (BMI ≥1.2 times the 95th percentile or ≥35 kg/m²). Participants received lifestyle counseling and were randomized to exenatide (twice daily) or placebo. Exenatide
This 12-week open-label, prospective study evaluated the efficacy of combining liraglutide (1.2 mg/day subcutaneously) with metformin (1000 mg twice daily) in 40 obese, non-diabetic women with PCOS who had previously lost less than 5% body weight on metformin monotherapy. Participants were randomized into three groups: metformin alone (MET), liraglutide alone
This systematic review and meta-analysis examined the effects of L-carnitine supplementation on body weight and composition, analyzing 37 randomized controlled trials with 2,292 participants. The findings showed that L-carnitine led to significant reductions in body weight (-1.21 kg, P < 0.001), BMI (-0.24 kg/m², P = 0.001), and fat mass
