Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis through the repression of NADPH Oxidase 4 and TGF-β1/Smad3 signaling pathways
This study explores the protective effects of alpha-lipoic acid (ALA) on bleomycin-induced skin fibrosis in a rat model, focusing on its role in reducing oxidative stress and inflammation. ALA treatment significantly decreased skin thickness and hydroxyproline content, indicating reduced fibrosis severity. Biochemical analyses showed ALA lowered malondialdehyde (MDA) levels, a
June 26, 2025
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