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Tag: bipolar androgen therapy

Supraphysiological Testosterone Therapy as Treatment for Castration-Resistant Prostate Cancer

This 2018 article explores the rationale and emerging evidence behind supraphysiological testosterone (SPT) therapy—specifically bipolar androgen therapy (BAT)—for castration-resistant prostate cancer (CRPC). BAT administers high-dose testosterone in cycles to exploit the overexpression of androgen receptors (AR) in CRPC cells, triggering DNA damage and AR pathway disruption. Clinical studies demonstrate potential

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June 26, 2025 No Comments

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study

This 2018 open-label, phase 2, multicohort study evaluated the efficacy of bipolar androgen therapy (BAT) in 30 men with metastatic castration-resistant prostate cancer (mCRPC) who had progressed after enzalutamide treatment. BAT involved intramuscular testosterone cypionate (400 mg every 28 days) combined with luteinizing hormone-releasing hormone agonist therapy. The primary endpoint,

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June 26, 2025 No Comments

Bipolar Androgen Therapy Sensitizes Castration-Resistant Prostate Cancer to Subsequent Androgen Receptor Ablative Therapy

This 2021 study evaluated the efficacy of bipolar androgen therapy (BAT) as a first-line treatment for castration-resistant prostate cancer (CRPC). In Cohort C of the RESTORE trial, 29 patients received 400 mg of testosterone cypionate every 28 days alongside luteinizing hormone-releasing hormone agonists or antagonists. The primary endpoint, PSA50 response

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June 26, 2025 No Comments

Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer

This 2017 editorial discusses bipolar androgen therapy (BAT) as a novel treatment strategy for castration-resistant prostate cancer (CRPC). BAT involves alternating testosterone levels between supraphysiologic and near-castrate concentrations, aiming to exploit the paradoxical effects of androgen exposure on tumor cells. Initial studies have shown that BAT is safe and can

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June 26, 2025 No Comments