Well Referenced

Tag: Biochemistry

The Essential Amino Acid Lysine Acts as Precursor of Glutamate in the Mammalian Central Nervous System

This 2000 study published in FEBS Letters uncovers a novel metabolic pathway in the mammalian brain, demonstrating that the essential amino acid lysine serves as a precursor for glutamate synthesis via the saccharopine pathway. Researchers identified that lysine undergoes transamination to form saccharopine, which is subsequently converted to α-aminoadipic semialdehyde

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June 26, 2025 No Comments

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

This study investigates the roles of nicotinamide riboside kinases (NRKs), specifically NRK1 and NRK2, in the metabolism of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) within skeletal muscle cells. Utilizing genetic knockout models and metabolic flux analyses, the researchers demonstrate that NRK1 and NRK2 exhibit functional redundancy in phosphorylating NR

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June 26, 2025 No Comments

Folate, vitamin B12 and vitamin B6 and one carbon metabolism

This review article discusses the crucial roles of folic acid, vitamin B12, vitamin B6, and vitamin B2 in one-carbon metabolism. These vitamins serve as coenzymes facilitating the transfer of one-carbon units essential for DNA and RNA synthesis, methylation reactions, and amino acid metabolism. Disruptions in this pathway, often due to

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June 26, 2025 No Comments