Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease
This 2022 review article examines the role of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in metabolic health and disease. Elevated BCAA levels are linked to insulin resistance, type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). BCAAs activate the mTORC1 pathway, influencing cell growth and glucose metabolism.
June 26, 2025
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