Melatonin influences pancreatic cancerogenesis
This 2014 review explores melatonin’s multifaceted role in modulating pancreatic cancer development. Melatonin acts as a potent antioxidant, scavenging reactive oxygen and nitrogen species, and enhancing antioxidant enzyme activity, thereby protecting pancreatic tissue from oxidative stress and inflammation. In pancreatic carcinoma cell lines, high doses of melatonin promote apoptosis via