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Tag: BAL

Arsenic Toxicity: Molecular Targets and Therapeutic Agents

This in-depth review outlines the molecular pathways affected by arsenic toxicity and surveys both conventional and emerging therapeutic strategies. Arsenic exposure—primarily via contaminated water and food—induces oxidative stress, mitochondrial dysfunction, epigenetic alterations, and DNA damage, contributing to carcinogenesis, cardiovascular disorders, and neurotoxicity. The review highlights the use of chelating agents

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June 26, 2025 No Comments

A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead

This review analyzes the coordination behavior and therapeutic potential of thiol-based chelators—DMSA, DMPS, BAL, and α-lipoic acid—against toxic metals mercury (Hg), cadmium (Cd), and lead (Pb). It outlines how these metals interact preferentially with sulfur-containing ligands due to their classification as soft or borderline acids. DMSA is noted for its

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June 26, 2025 No Comments

Metal chelators and neurotoxicity: lead, mercury, and arsenic

This review examines the use of metal chelators, including DMSA, DMPS, and CaEDTA, in treating lead, mercury, and arsenic poisoning, with a focus on their efficacy, safety, and potential combination therapies. The study highlights that DMSA is a safer alternative to CaEDTA for moderate lead poisoning and suggests that DMSA

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June 26, 2025 No Comments