Well Referenced

Tag: azoospermia

Efficacy and Outcome Predictors of Gonadotropin Treatment for Male Congenital Hypogonadotropic Hypogonadism: A Retrospective Study of 223 Patients

This retrospective study analyzed 223 azoospermic men with congenital hypogonadotropic hypogonadism (CHH) treated with combined human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) over a median follow-up of 15 months. Results showed that 64% of patients achieved spermatogenesis, with a median time to sperm appearance of 15 months. Significant

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June 26, 2025 No Comments

The Use of HCG-Based Combination Therapy for Recovery of Spermatogenesis after Testosterone Use

This 2015 case series evaluated 49 men with testosterone-induced azoospermia or severe oligospermia who underwent combination therapy with human chorionic gonadotropin (HCG) and adjunctive agents such as clomiphene citrate, tamoxifen, anastrozole, or recombinant follicle-stimulating hormone. Administered HCG at 3,000 IU subcutaneously every other day, the study observed a 95.9% recovery

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June 26, 2025 No Comments

Preserving fertility in the hypogonadal patient: an update

This 2015 review addresses the challenge of managing hypogonadism in men desiring fertility preservation. Exogenous testosterone therapy can suppress the hypothalamic-pituitary-gonadal axis, leading to impaired spermatogenesis and potential azoospermia. The authors highlight alternative treatments, such as human chorionic gonadotropin (hCG), which can stimulate endogenous testosterone production and maintain intratesticular testosterone

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June 26, 2025 No Comments