Well Referenced

Tag: autism spectrum disorder

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

This 36-week Phase II randomized, double-blind, placebo-controlled trial evaluated the safety, tolerability, and efficacy of sulforaphane (SF) in 57 children aged 3–12 years with autism spectrum disorder (ASD). Participants received either SF (derived from broccoli seed and sprout extract tablets containing glucoraphanin and active myrosinase, yielding approximately 15 µmol SF

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June 26, 2025 No Comments

Role of NAD(+), Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders

This 2013 review examines the biochemical underpinnings of autism spectrum disorder (ASD), focusing on oxidative stress, mitochondrial dysfunction, and tryptophan metabolism. It highlights that individuals with ASD often exhibit elevated oxidative stress markers and diminished antioxidant defenses, leading to mitochondrial impairments and disrupted energy metabolism, including alterations in NAD⁺/NADH ratios

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June 26, 2025 No Comments

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

This open-label clinical trial assessed the impact of folic acid supplementation on behavioral and biochemical parameters in children with autism spectrum disorder (ASD) undergoing structured teaching. Sixty-six children participated, with 44 receiving 400 μg of folic acid twice daily for three months, while 22 served as controls. Behavioral assessments using

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June 26, 2025 No Comments