Well Referenced

Tag: Atypical Antipsychotics

Metformin for Weight Reduction in Non-Diabetic Patients on Antipsychotic Drugs: A Systematic Review and Meta-Analysis

This 2011 systematic review and meta-analysis evaluated the efficacy of metformin in mitigating weight gain induced by atypical antipsychotics in non-diabetic patients. Analyzing seven randomized, placebo-controlled trials encompassing 398 participants (five studies in adults and two in children), the study found that metformin significantly reduced body weight compared to placebo.

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June 26, 2025 No Comments

Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism

This 2011 review by Teff and Kim explores how atypical antipsychotics (AAPs) influence central and peripheral mechanisms regulating appetite and metabolism. AAPs, notably clozapine and olanzapine, are associated with significant weight gain and metabolic disturbances. The authors discuss how these drugs affect hypothalamic pathways, particularly through antagonism of histamine H1

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June 26, 2025 No Comments

Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis

This 2022 systematic review and network meta-analysis evaluated 65 randomized controlled trials encompassing 12,415 patients with treatment-resistant depression (TRD). The study compared the efficacy and discontinuation rates of 19 augmentation agents, including stimulants, atypical antipsychotics, thyroid hormones, antidepressants, and mood stabilizers. Significant response rates were observed with liothyronine, nortriptyline, aripiprazole,

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June 26, 2025 No Comments